Antiepileptic drugs (AEDs) used in monotherapy or polytherapy do not pose an increased risk for sudden unexpected death in epilepsy (SUDEP), but polytherapy – particularly with lamotrigine, valproic acid, and levetiracetam – or monotherapy with levetiracetam, was associated with reduced risk of SUDEP. Statins may also be protective for SUDEP.
Why this matters ?
While there is an urgent need to reduce the risk of SUDEP, data on the contribution of AEDs are limited. Understanding the relationship between AEDs and SUDEP risk may improve clinical outcomes.