Investigating microvascular non-reperfusion following successful thrombectomy


  • Regions of microvascular non-reperfusion (‘no-reflow’) despite complete upstream macrovascular reperfusion are common, and associated with increased risk of complications, dependence, and death.

Why this matters ?

  • Despite timely and complete angiographic reperfusion following thrombectomy in large vessel occlusions, a significant number of patients have poor functional outcomes.

  • It is possible that incomplete microvascular reperfusion – regions of ‘no-reflow’ – could contribute to poor outcomes; however, despite good pre-clinical evidence, the existence of no-reflow and its potential effects in humans remain controversial.