Alzheimer’s disease (AD)-like changes in default mode network (DMN) connectivity were observed in patients with dementia with Lewy bodies (DLB) who had a higher burden of AD co-pathology, and the pattern of tau distribution was associated with the brain’s functional network structure.
Why this matters
DLB is typically defined by the presence of Lewy bodies. However, many cases also exhibit AD pathology, which is associated with a more rapid cognitive decline.
Functional connectivity studies of AD have shown decreased connectivity of the DMN, but it is unclear how this network is affected in DLB.