Dysregulated lysosomal enzyme activity may be an early sign of Parkinson’s disease

Takeaway

  • Defective trafficking and metabolism of serum lysosomal acid hydrolase activity is strongly correlated with both idiopathic Parkinson’s disease (PD) and parkinsonian syndrome (PS).

Why this matters

  • Serum lysosomal acid hydrolase activity is a potential peripheral biomarker for detection of PD, which would allow for early intervention leading to improved patient outcomes.